Association of EASIX in Sepsis

Sisli Hamidiye Etfal Training and Research Hospital150 enrolled

Overview

This prospective study aims to determine the relationship between the EASIX score and mortality and prognosis in sepsis.

Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to organ dysfunction. Despite advancements in medicine, sepsis remains a significant cause of death worldwide. An international study showed that 48.9 million sepsis cases were diagnosed in 195 countries between 1990 and 2017, resulting in 11 million deaths. Recent studies have demonstrated that early diagnosis and treatment reduce sepsis mortality. Therefore, research has focused on identifying biomarkers that aid in early diagnosis and prognosis. The Endothelial Activation and Stress Index (EASIX) was first defined by Luft et al. as a biomarker reflecting endothelial damage. Calculated using readily available laboratory parameters-serum lactate dehydrogenase (LDH) level (U/L) x creatinine level (mg/dL) / platelet count (10⁹/L)-it has been commonly used to predict mortality and prognosis in hematological malignancies. Recently, its application in predicting sepsis mortality and prognosis has gained attention, although only limited retrospective studies have been published.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Sepsis Septic Shock Septic Syndrome

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * • Patients diagnosed with sepsis during intensive care admission or admitted to intensive care with a diagnosis of sepsis * All patients over the age of 18 Exclusion Criteria: * • Patients under the age of 18 * Patients with a history of multiple intensive care admissions * Patients who died within 24 hours of diagnosis * Patients diagnosed with CRF or currently treated for ARF * Patients with deficient serum creatinine, LDH and platelet values at the time of diagnosis Patients for whom consent could not be obtained from themselves or their relatives

Locations (1)

Sisli etfal research and training hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

mortality

The primary finding of the study was 28-day mortality after sepsis diagnosis

Time frame: 28 days

Secondary Outcomes

Septic shock

Septic shock was defined according to the SEPSIS-3 guidelines as the need for vasopressors or inotropes in patients diagnosed with sepsis.

Time frame: 28 days

Acute kidney injury

Acute kidney injury was defined according to KDIGO guidelines as a ≥0.3 mg/dL increase in serum creatinine over 48 hours, a ≥1.5-fold increase in serum creatinine over 7 days, or urine output \<0.5 mL/kg/hour for 6 consecutive hours.

Time frame: 28 days

Data from ClinicalTrials.gov

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