Project on tDCS Intervention to Enhance Advanced Social Cognitive Functions in Drug Rehabilitation Individuals

N/AEnrolling By InvitationNCT06888700

Shaanxi Normal University84 enrolled

Overview

This project aims to explore key brain functional and biochemical indicators associated with impaired advanced social cognition through an integrated approach encompassing unconscious control, conscious control, cognitive flexibility, problem-solving, and social interaction domains. By incorporating multimodal measures spanning physiological, neural, cognitive, psychological, and behavioral dimensions, we will develop a comprehensive intervention protocol combining course-based brain stimulation and cognitive training. The study will employ a multi-timepoint, multi-level assessment framework to track the enhancement of higher cognitive functions and brain functional recovery in individuals undergoing drug rehabilitation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Drug Addiction

Interventions

The participant cohort recruited for this study consists of individuals with substance use disorder (SUD), specifically those addicted to drugs. During the intervention phase, this group will adhere to a strict non-pharmacological intervention protocol, meaning they will not receive any form of pharmacotherapy, neurosurgical intervention, or other neuromodulation-based cognitive interventions, including but not limited to techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). This design aims to ensure the internal validity of the study results and to exclude potential confounding effects of other interventions on neuroplasticity and cognitive function.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age between 30 and 60 years; * fulfilling the diagnostic criteria for severe substance use disorder as specified in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders. * a history of heroin use exceeding ten years, with a daily average intake of at least 0.1 grams. * abstinence duration of eight months or less, with a positive result of a urine test before entering the rehabilitation center. * no history of neuromodulation treatments such as tDCS within the past six months. Exclusion Criteria: * a history of alcohol dependence, neurological disorders, or other complex psychiatric conditions. * the presence of intracranial metallic implants or elevated intracranial pressure. * a history of epilepsy or recent electroencephalogram evidence of epileptiform activity. * the use of implanted electronic devices, such as pacemakers;. * scalp hyperalgesia or a tendency toward bleeding. * severe cardiac conditions.