Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients with Hypertensive Angiopathy or Cerebral Amyloid Angiopathy

N/ANot Yet RecruitingNCT06888882

Centre Hospitalier Universitaire de Nīmes72 enrolled

Overview

Hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA) are the two most common forms of cerebral small vessel disease. On MRI, chronic small vessel disease-related abnormalities include white matter hyperintensities, dilated perivascular spaces (DPVS), lacunar infarction, and hemorrhagic features (e.g. cerebral microbleeds, CMB). In the cerebellum, deep CMB involving the dentate nucleus (DN) is associated with HA, whereas the presence of superficial cerebellar CMB are associated with CAA. DPVS are observed in both diseases, predominant in the subcortical white matter (especially in the centrum semiovale) in CAA whereas HA-related DPVS are predominant deep in the brain inside or nearby the basal ganglia. To the best of our knowledge, DN-DPVS have never been studies systematically in small vessel disease. The researchers want to study DN-DPVS on T2-weighted 3T MRI in patients with HA or CAA and to compare both groups.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypertensive Arteriopathy Cerebral Amyloid Angiopathy

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient registered in the CHU de Nîmes (France) stroke database with lobar intracerebral hemorrhage \[ICH\], subarachnoid hemorrhage or cortical superficial siderosis for CAA or basal ganglion ICH for HA * Patient managed at the CHU de Nîmes (France) between 01/1/2015 and 31/12/2024 * Patient with T2-weighted MRI performed with a 3T magnet Exclusion Criteria: * Refusal to participate

Outcomes

Primary Outcomes

Sex

Comparaison of both populations (HA/CAA), H/F

Time frame: baseline

Hypertension

history of hypertension (Yes/No)

Time frame: baseline

Age

Age at time of T2-weighted imaging,

Time frame: baseline

Time

Time between initial MRI-based CAA/HA diagnosis and 3T T2-weighted imaging, axial or coronal views of T2 imaging,

Time frame: baseline

MRI view

T2 performed using coronal or axial imaging (axial / coronal

Time frame: baseline

hypercholesterolemia

history of hypercholesterolemia (Yes/No)

Time frame: baseline

Hemorrhagic lesion

Hemorrhagic lesion load on T2\*-weighted imaging (ICH and CMB for both CAA and HA, and subarachnoid hemorrhage/cortical superficial siderosis for CAA)

Time frame: baseline

Subcortical lobar DPVS

Semi-quantitative score for evaluation of subcortical lobar DPVS (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).

Time frame: baseline

DPVS of basal ganglia

Semi-quantitative score for evaluation of DPVS of basal ganglia (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).

Time frame: baseline

Diabete

history of diabetes (Yes/No)

Time frame: baseline

Smoking

current smoking (Yes / No)

Time frame: Baseline

Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients with Hypertensive Angiopathy or Cerebral Amyloid Angiopathy

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts