Hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA) are the two most common forms of cerebral small vessel disease. On MRI, chronic small vessel disease-related abnormalities include white matter hyperintensities, dilated perivascular spaces (DPVS), lacunar infarction, and hemorrhagic features (e.g. cerebral microbleeds, CMB). In the cerebellum, deep CMB involving the dentate nucleus (DN) is associated with HA, whereas the presence of superficial cerebellar CMB are associated with CAA. DPVS are observed in both diseases, predominant in the subcortical white matter (especially in the centrum semiovale) in CAA whereas HA-related DPVS are predominant deep in the brain inside or nearby the basal ganglia. To the best of our knowledge, DN-DPVS have never been studies systematically in small vessel disease. The researchers want to study DN-DPVS on T2-weighted 3T MRI in patients with HA or CAA and to compare both groups.
Study Type
OBSERVATIONAL
Enrollment
72
CHU de Nîmes
Nîmes, Occitanie, France
Sex
Comparaison of both populations (HA/CAA), H/F
Time frame: baseline
Hypertension
history of hypertension (Yes/No)
Time frame: baseline
Age
Age at time of T2-weighted imaging,
Time frame: baseline
Time
Time between initial MRI-based CAA/HA diagnosis and 3T T2-weighted imaging, axial or coronal views of T2 imaging,
Time frame: baseline
MRI view
T2 performed using coronal or axial imaging (axial / coronal
Time frame: baseline
hypercholesterolemia
history of hypercholesterolemia (Yes/No)
Time frame: baseline
Hemorrhagic lesion
Hemorrhagic lesion load on T2\*-weighted imaging (ICH and CMB for both CAA and HA, and subarachnoid hemorrhage/cortical superficial siderosis for CAA)
Time frame: baseline
Subcortical lobar DPVS
Semi-quantitative score for evaluation of subcortical lobar DPVS (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
Time frame: baseline
DPVS of basal ganglia
Semi-quantitative score for evaluation of DPVS of basal ganglia (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
Time frame: baseline
Diabete
history of diabetes (Yes/No)
Time frame: baseline
Smoking
current smoking (Yes / No)
Time frame: Baseline
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