Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. This makes rational fluid management difficult, which is of high importance for patient-related outcomes. The availability of carbon monoxide(CO)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume. The purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. Furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.
Study Type
OBSERVATIONAL
Enrollment
25
Hvidovre University Hospital
Copenhagen, Denmark
Change in total blood volume (TBV)
Measured in milliliter (mL)
Time frame: Preoperatively and 6 hours postoperatively
Change in total blood volume (TBV)
measured in mL
Time frame: Preoperatively and 24 hours postoperatively
Changes in total hemoglobin mass (tHgb)
Measured in gram (g)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in erythrocyte volume (EBV)
Measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in plasma volume (PV)
Measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in hematokrit (Ht)
Reported as percentage(%)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in hemoglobin (Hg) concentration
Measured in millimoles/liter(mmol/L)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in Total body water(TBW), intra-(ICF) and extracellular(ECF) fluid distribution
Full body water via bioelectrical impedance analysis. The individual components are reported in L and percent.
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in C-Reactive Protein (CRP)
Measured in milligram/liter (mg/L)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Incidence of orthostatic intolerance during mobilization
Symptoms of orthostatic intolerance: dizziness, nausea, vomiting, blurry vision or syncope during mobilization
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between total blood loss and incidence of orthostatic intolerance
Blood loss measured in mL. Symptoms of orthostatic intolerance: dizziness, nausea, vomiting, blurry vision or syncope during mobilization
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between changes in C-Reactive Protein and total blood loss
C-Reactive Protein measured in mg/L and total blood loss measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between peripheral perfusion index and total blood loss
Peripheral perfusion index measured in percent and total blood loss in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between total hemoglobin (SpHb) and total blood loss
SpHb measured as gram/deciliter and total blood loss measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
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