Targeted Α-synuclein PET Imaging in the Diagnosis of Multiple System Atrophy

Min Zhao,MD90 enrolled

Overview

The aim of this study was to apply the targeted α-synuclein PET study technique to investigate the pathological load and spatial distribution characteristics of α-syn in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis in MSA.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple System Atrophy - Cerebellar Subtype (MSA-C)Multiple System Atrophy - Parkinsonian Subtype (MSA-P)

Eligibility

Sex: ALLMin age: 35 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age\> 35 years old, gender is not limited; * Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria; * all patients had been ruled out of polyQ disease by genetic testing; * Voluntarily participate in this study and sign the informed consent form. Exclusion Criteria: * pregnancy or breastfeeding; * contraindications to MRI examination or inability to cooperate in completing neuroimaging examination; * previous history of other neurological disorders or presence of other organic intracranial lesions on neuroimaging that cannot be interpreted by MSA, such as epilepsy, trauma, tumors, or high-grade cerebral white matter degeneration (Fazekas grade 2 and above); * History of alcohol or drug abuse

Locations (1)

Third Xiangya Hospital of Central South University

Hunan, Changsha, China

RECRUITING