The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP). The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 18 years old diagnosed with severe CAP. The main question is whether there is a difference in all cause mortality within thirty days. Participants will be randomized to receive treatment with either hydrocortisone or prednisolone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
1,600
ATC code: H02AB06. Can be changed to Prednisolone 50 mg orally.
ATC-code: H02AB09. Can be changed to 50 mg x 4 daily orally if appropriate.
Bornholm Hospital
Rønne, Bornholm, Denmark
RECRUITINGAmager Hospital
Copenhagen, Copenhagen City, Denmark
All-cause mortality
Time frame: 30 days
All-cause mortality
Time frame: 90 days
All-cause infections
Time frame: 90 days
Need for vasopressor treatment
Time frame: 30 days
Need for mechanical ventilation
Time frame: 30 days
Admission to ICU
Time frame: 30 days
Daily amount of insulin administered to the patient by day 7 or discharge from hospital
Time frame: 7 days
Gastrointestinal bleeding
Time frame: 30 days
Blood glucose levels
Measured at day 3 and day 7.
Time frame: 7 days
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Bispebjerg Hospital
Copenhagen, Copenhagen City, Denmark
RECRUITINGFrederiksberg Hospital
Frederiksberg, Copenhagen City, Denmark
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Hellerup, Copenhagen City, Denmark
RECRUITINGHerlev Hospital
Herlev, Copnhagen Surroundings, Denmark
RECRUITINGHvidovre Hospital
Hvidovre, Copnhagen Surroundings, Denmark
RECRUITINGNordsjællands Hospital
Hillerød, North Zealand, Denmark
RECRUITINGHolbæk Sygehus
Holbæk, Region Sjælland, Denmark
RECRUITINGUniversity Hospital of Region Zealand, Køge
Køge, Region Sjælland, Denmark
RECRUITING...and 4 more locations