The purpose of this study is to evaluate the effects of concentrated growth factor (CGF) on edema after bilateral impacted third molar surgery and to determine its contribution to the healing process. The main question it aims to answer is: Is CGF effective on reducing the edema in impacted third molar surgery? Researchers compare the edema amount on the CGF-applied and CGF free sides after impacted third molar surgery. The edema measurements are performed on the second and seventh days.
It has been observed that the treatment of impacted tooth extraction, which is the most commonly performed interventional procedure in oral and maxillofacial surgery clinics and affects the patient's comfort and daily life after the operation, has been investigated in many ways and new ideas are constantly emerging. Wound healing is a process controlled by many intracellular and extracellular mechanisms. In recent years, many studies have been conducted to make this process faster and more successful, and it has been observed that the use of platelet products in this area has yielded extremely successful results. Concentrated Growth Factor (CGF), which has gained an important place in regenerative medicine in recent years, has attracted attention due to its potential to minimize postoperative complications. This randomized clinical trial was conducted at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ege University. Forty-nine patients, regardless of gender, with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted third molar in the mandible and without any systemic disease are included in the study. Before the impacted third molar surgery, detailed medical and dental history are taken from the patients. The patients are informed in detail about the drugs to be used in the study, the applied method, the duration and purpose of the study. In order to obtain the data required for statistical analysis of the amount of edema on the sides where CGF is used and not used after the operation, edema measurements are made at three points on the patients before the operation, on the 2nd and 7th days after the operation. These measurements are made between the external canthus-angulus mandible, tragus-commissura and tragus-pogonium. Wilcoxon Signed Ranks test is used to compare the means of two dependent samples and to determine the significance of the difference between them.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
49
Bilaterally impacted third molar of the patients areremoved surgically and concentrated growth factor isplaced in one of the extraction sockets.
The other extraction socket is left empty for control purposes.
Ege University Faculty of Dentistry
Izmir, Bornova, Turkey (Türkiye)
Postoperative edema amounts on CGF-applied and CGF free sides in bilateral impacted third molar surgery
Edema measurements are made at three points on the patients before the operation, on the 2nd and 7th days after the operation. These measurements are made between the external canthus-angulus mandible, tragus-commissura and tragus-pogonium. In order to ensure standardization, all measurements are made by the same physician with the patient's head position in the same direction.
Time frame: Before operation to the end of the operation at seven days
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