The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery. Renin is a protein that may be elevated in response to low blood pressure or situations where organs do not receive sufficient oxygen. Renin may potentially be used as an indicator for specific treatments aimed to increase the blood pressure. This study will evaluate blood samples for renin concentration throughout the course of open heart surgery.
The investigator hypothesizes that renin concentrations will increase with exposure to cardiopulmonary bypass and that increased renin concentrations will be associated with the development of vasoplegia. Specific Aim 1. To characterize the effects of cardiopulmonary bypass on plasma renin concentrations in adults undergoing cardiac surgery. Specific Aim 2. To test the prognostic value of plasma renin concentrations on outcomes following cardiac surgery.
Study Type
OBSERVATIONAL
Enrollment
100
Mayo Clinic
Rochester, Minnesota, United States
RECRUITINGPlasma renin concentrations
Time frame: Up to 24 hours after surgery
Vasoplegia
Requirement of any vasopressor to maintain a mean arterial pressure of 65 mmHg or greater despite a cardiac index of at least 2.2 L/min/m2 with or without the need for pharmacologic inotropy
Time frame: First 24 hours postoperative
Acute kidney injury
Assessed by the Kidney Disease Improving Global Outcomes (KDIGO) staging criteria
Time frame: 7 days
Organ dysfunction
The presence of any organ support therapy including vasopressors, renal replacement therapy, and mechanical ventilation
Time frame: 28 days
Mortality
Time frame: 28 days
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