The objective of this study is to test the effect of 12 weeks of supplementation SRW Ndo1 on metabolic health and general health in adults with prediabetes. The primary question it aims to answer are: * How does SRW Ndo1 affect the Haemoglobin A1C (HbA1C) test outcome for adult individuals? * How does SRW Ndo1 affect the body measures and blood pressures of adult individuals? Investigators will compare the supplement to a placebo (a look-alike substance that contains no supplement) to see if SRW Ndo1 works to support normal blood sugar metabolism. Participants will: * Take supplement SRW Ndo1, two capsules a day for 12 weeks. * Be asked to refrain from changing their diet and lifestyle drastically during the study and to refrain from starting new health supplements during the study. * Visit the clinic at the start and the end of intervention for a blood test (8 hour fasting required prior to test) * Keep a diary of their symptoms or adverse events during intervention.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
14
The investigational product (IP) is a health supplement for glycaemic control. Each capsule contains 80 mg of dahlia4® (Dahlia pinnata extract), 80 mg of Eriomin® (Citrus limon extract), and 100 mg of Mulberry leaf extract (with 5% 1-deoxynojirimycin).
Baohua
Guangzhou, Guandong, China
Serum Hemoglobin A1C (HbA1c) concentration
Measured in mmol/mol. Normal range: \<5.7
Time frame: From enrollment to the end of treatment at 12 weeks
Fasting plasma glucose concentration
Measured in mg/dL
Time frame: From enrollment to the end of treatment at 12 weeks
Weight
Measured in kg
Time frame: From enrollment to the end of treatment at 12 weeks
Body Mass Index (BMI)
Measured in kg/m\^2. Optimal range: 18.5-24.9.
Time frame: From enrollment to the end of treatment at 12 weeks
Waist circumference
Measured in cm
Time frame: From enrollment to the end of treatment at 12 weeks
Blood lipids
Total Cholesterol (TC): Normal: \<5.2 mmol/L Borderline High: 5.2-6.2 mmol/L High: ≥6.2 mmol/L Triglycerides (TG): Normal: \<1.7 mmol/L Borderline High: 1.7-2.3 mmol/L High: ≥2.3 mmol/L Low-Density Lipoprotein Cholesterol (LDL-C): Normal: \<3.4 mmol/L Borderline High: 3.4-4.1 mmol/L High: ≥4.1 mmol/L High-Density Lipoprotein Cholesterol (HDL-C): Normal for Men: \>1.0 mmol/L Normal for Women: \>1.3 mmol/L Low: \<1.0 mmol/L for Men, \<1.3 mmol/L for Women
Time frame: From enrollment to the end of treatment at 12 weeks
Liver functions test
Alanine Aminotransferase (ALT): Normal: 0-40 U/L Aspartate Aminotransferase (AST): Normal: 0-40 U/L Alkaline Phosphatase (ALP): Normal: 40-150 U/L Total Bilirubin (TBIL): Normal: 3.4-17.1 μmol/L Gamma-Glutamyl Transferase (GGT): Normal: \<60 U/L for men, \<40 U/L for women
Time frame: From enrollment to the end of treatment at 12 weeks
Hs-CRP test
Measured in mg/L. Optimal: \<1.0 mg/L
Time frame: From enrollment to the end of treatment at 12 weeks
Systolic and diastolic blood pressure
Measured in mmHg. Optimal range: \<120/80 mmHg.
Time frame: From enrollment to the end of treatment at 12 weeks
Energy questionnaire
Measured using a 100-point Likert scale. 1 is 'extremely low energy' and 100 is 'extremely high energy'
Time frame: From enrollment to the end of treatment at 12 weeks
Hunger and satiety questionnaire
Measured using a 100-point Likert scale. 1 is 'extremely unsatisfied' and 100 is 'extremely satisfied'
Time frame: From enrollment to the end of treatment at 12 weeks
Mood questionnaire
Measured using a 100-point Likert scale. 1 is 'extremely stressed' and 100 is 'no stress at all'
Time frame: From enrollment to the end of treatment at 12 weeks
Gastrointestinal symptoms questionnaire
Measured using a 100-point Likert scale. 1 is 'No symptoms' and 100 is 'very severe symptoms'
Time frame: From enrollment to the end of treatment at 12 weeks
Hypoglycemia events frequency questionnaire
Measured using a 100-point Likert scale. 1 is 'None at all' and 100 is 'extremely high frequency'
Time frame: From enrollment to the end of treatment at 12 weeks
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