The purpose of this study is to compare better postoperative analgesia after lumbar spine Fixation using either epidural bupivacaine with midazolam or fentanyl with the combination of dexamethasone.
After being informed about the study and potential risks. A computer-generated randomization table will randomize all patients giving written consent into 2 groups, each containing 51 patients. In the Fentanyl Group :.Patients will receive 10 ml of bupivacaine 0. 25 % plus 100µg fentanyl in 2ml plus 2ml (8mg) dexamethasone.In Midazolam Group: Patients will receive 10 ml of bupivacaine 0.25 % plus 2mg midazolam in 2ml plus 2 ml (8mg) dexamethasone
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
Fentanyl will be injected in the epidural space by the surgeon one or two levels above the surgical site.
midazolam will be injected in the epidural space by the surgeon one or two levels above the surgical site.
Faculty of Medicine,Zagazig University
Zagazig, Egypt
the time to first call to rescue analgesia (ketorolac)
Time frame: day 1
The Numerical Pain Rating Scale
A ten-centimeter Numerical Pain Rating Scale (0 - no pain and 10 - worst pain)
Time frame: 24 hours postoperative]
The total postoperative opioid consumption in the first 24 hours. opioid consumption
Time frame: 24 hours postoperative
the duration of hospital stay
from the post operative day till discharge from hospital.
Time frame: up to 1 week
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.