The Effects of Intravenous Iron on Mobility in Elderly Patients Following Hip Fracture Surgery

Hemoglobin

Time frame: Measured at baseline, 6 and 12 weeks after intervention.

Red blood cell transfusion requirement

This will be measured by the proportion of patients who receive at least one red blood cell unit and the amounts of units per patient

Time frame: Measured on postoperative day (POD) 7 and POD 30

Fatigue, assessed using the Verbal Rating Scale for Fatigue (F-VRS)

Fatigue will be assessed using the Verbal Rating Scale for Fatigue (F-VRS). This scale, ranging from 0 to 4, measures fatigue in hip fracture patients, where 0 indicates no fatigue and 4 represents extreme fatigue.

Time frame: Measured at baseline, 4, 6 and 12 weeks after intervention.

Quality of life with EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L )

The EQ-5D-5L questionnaire measures health-related quality of life across five dimensions, with scores ranging from 1 (no problems) to 5 (extreme problems). Higher scores indicate worse outcomes, reflecting greater health issues.

Time frame: Measured as a retrograde baseline the weeks prior to admission and at 6 and 12 weeks after intervention

EuroQol Visual Analogue Scale (EQ VAS 0-100)

The EQ VAS 0-100 (range) is a visual analogue scale where 0 represents the worst imaginable health state and 100 represents the best. Higher scores on the EQ VAS indicate a better health outcome.

Time frame: Measured as a retrograde baseline the weeks prior to admission and at 6 and 12 weeks after intervention

Fear of falls measured with, Short Falls Efficacy Scale International (Short-FES-I)

Short Falls Efficacy Scale International (Short-FES-I) measures concern about falling during various activities, with scores ranging from 7 (no concern about falling) to 28 (severe concern about falling). Higher scores indicate greater concern about falling.

Time frame: Measured at baseline and at 6 and 12 weeks after intervention.

30 second Sit-to-Stand-Test (STS)

Participants are encouraged to stand and fully sit as many times as possible within 30 seconds, with correct form monitored by the tester. If a participant uses their arms, they score a 0, and only correctly executed stands are counted. This test assesses a wide range of ability levels. Lower score indicates worse outcome.

Time frame: Measured at baseline, 6 and 12 weeks

Activity of daily living, asessed with Barthel Index 20

Barthel 20 Index measures a patient's level of independence in daily activities, with scores ranging from 0 (complete dependence) to 20 (complete independence). Higher scores indicate a better outcome, reflecting greater independence.

Time frame: Measured as a retrograde baseline and at 6 and 12 weeks after intervention

Pain, assessed using the Verbal Rating Scale for pain

Hip fracture-related pain will be assessed using the Verbal Rating Scale for Pain, which ranges from 0 to 4. A score of 0 indicates no pain, while a score of 4 represents unbearable or the worst imaginable pain

Time frame: Measured at baseline and at 6 and 12 weeks after intervention

Days alive and at home up to 30 (DAH30)

The DAH30 is determined using a combination of electronic medical records (obtaining length of stay) and direct participant inquiries at the 6 week follow up

Time frame: Measured at 6 weeks after intervention.

Serious adverse event (SAE)

SAE defined following the ICH - GCP guidelines

Time frame: Will be assessed up to the 6 weeks follow up

Mortality

The time of death is determined using validated registry-based data, from which survival rates, as well as 30-day and 90-day mortality rates, are calculated.

Time frame: 90 days