Does Botulinum Toxin Type-A Injection an Effective Way of Relieving Pain in Myofascial Pain Syndrome Patients or Not

Bursa City Hospital38 enrolled

Overview

In this research prilocaine and botulinum toxin (BoNT-A) interventions prospectively compared to find out the effect of BoNT-A injection on myofascial pain syndrome (MPS). The main question it aims to answer is: Does Botulinum Toxin Type-A an Effective Way of Relieving Pain in Myofascial Pain Syndrome or not? For this purpose thirty-eight patients randomly assigned into two study groups. While BoNT-A injection group (BIG group n=19) treated with 20 units of toxin to each trigger point (TP), remaining treated with 2 ml prilocaine (PIG group n=19) with same procedure. Pre-treatment, 2nd and 6th weeks findings were clinically recorded.

Visual Analog Scale (VAS), 4-Point Verbal Rating Scale (VRS), Pain Pressure Threshold (PPT), Short Form-36 (SF-36) and Beck Depression Inventory (BDI) tools were used to evaluate findings of the research.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Myofacial Pain Syndromes

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: Age ≥ 20 years Presence of myofascial pain syndrome (MPS) symptoms for more than 3 months Ability and willingness to provide written informed consent Exclusion Criteria: Any injection to trigger points within the last 2 months Diagnosis of fibromyalgia syndrome Presence of significant respiratory or cardiovascular disease Presence of psychiatric disorders that may interfere with study participation History of shoulder or cervical spine intervention within the last year Presence of cervical myelopathy or cervical radiculopathy Inability to cooperate with study procedures or assessments

Outcomes

Primary Outcomes

Visual analog scale, 4-point verbal rating scale, Pressure pain threshold

Visual analog scale (VAS) between 0 and 10 was used to measure subjective complaints of pain (0 painless-10 worst pain). 4-point verbal rating scale (VRS) was also used to evaluate the affected area covering the TP (3 Severe pain; strong verbal response, accompanied by grimacing of face, withdrawal of hand, 2 Modarate pain, complaint reported spontaneously or mostly response to asking, accompanied by behavioral changes like grimacing, 1 Mild pain, pain is expressed when questioning without behavioral responces and 0 None, no pain). An algometry device is used to evaluate "Pressure pain threshold" (PPT) and the sensitivity that the person felt is recorded in kg.

Time frame: Pre-treatment, 2nd and 6th week scores were recorded.