Perfusion Parameters and Outcome During a Standardized Deresuscitation Strategy with Net Ultrafiltration: a Retrospective Cohort Study.

Hospices Civils de Lyon120 enrolled

Overview

Hemodynamic tolerance of fluid removal during deresuscitation is a cornerstone of the impact on outcome of such a strategy. However, how to define and to predict hemodynamic tolerance to fluid removal remains controversial. The investigators routinely use a standardized deresuscitation protocol in patients with fluid overload and continuous renal replacement therapy combined with monitoring of clinical and biological perfusion parameters. The aim of the study was to describe perfusion during deresuscitation, and to determine whether it is associated with major adverse kidney events at day 30.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Fluid Overload Acute Kidney Injury Continuous Renal Replacement Therapy

Interventions

Describe the perfusion parameters during a deresuscitation strategy and their association with the outcome.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years old * Acute kidney injury requiring continuous renal replacement therapy * Standardized deresuscitation following a routine care protocol Exclusion Criteria: * Chronic hemodialysis * Advanced directives to withhold or withdraw life-sustaining treatment, * Patient's opposition to the use of his/her personal health data

Outcomes

Primary Outcomes

MAKE 30

Major adverse kidney event at day 30, defined as follows: * Death OR * No weaning of renal replacement therapy OR * Serum creatinine \> 2 times baseline serum creatinine

Time frame: A day 30 after the initiation of the deresuscitation strategy