The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery

N/ANot Yet RecruitingNCT06899971

Boston Children's Hospital100 enrolled

Overview

Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid much attention. This study is to determine the relationship between specific proteins in the blood and brain injury in patients less than 18-year-old undergoing heart surgery.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Cardiac Surgery Requiring Cardiopulmonary Bypass Brain Injury Congenital Heart Defect

Interventions

Collecting discarded blood samplesOTHER

Discarded blood samples will be collected from routine clinical labs collected before and after surgery.

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * less than 18 years old * undergoing cardiac surgery with cardiopulmonary bypass at Boston Children's Hospital Exclusion Criteria: * undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent * patient in a moribund condition American Society of Anesthesiology (ASA 5) * patient with a hematological and/or oncological disease * Jehovah witnesses * patient on preoperative mechanical ventilation

Outcomes

Primary Outcomes

Characterization of postoperative neurological impairment

Understand the correlation between measured proinflammatory cytokines and several proteins that are highly expressed in brain cells with postoperative neurological status.

Time frame: 24 hours following surgery