Metabolic Imaging of Neurological Disease

N/AEnrolling By InvitationNCT06900244

University of Oxford250 enrolled

Overview

Multiple Sclerosis is a chronic condition that shows changes in the way that the brain consumes sugar. It is also known that there are a number of metabolic and inflammatory sequelae following a transient ischemic attack/stroke (hereby referred to collectively as 'stroke'). This study will use a powerful new technology ('hyperpolarised magnetic resonance imaging') to detect these changes in the brains of people with multiple sclerosis and Clinically Isolated Syndrome (CIS) or following a stroke when compared to a group of healthy volunteers. It will be undertaken at the University of Oxford, and each participant will undergo up to 4 scans over the course of three years.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Multiple Sclerosis

Eligibility

Sex: ALLMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of MS or stroke Exclusion Criteria: \-

Locations (1)

University of Oxford

Oxford, United Kingdom

Outcomes

Primary Outcomes

To detect 13C metabolism in healthy participants and MS, CIS, and Stroke patients.

Baseline: Imaging of 13C labelled downstream metabolites from the injected metabolically active substrates in healthy participants and MS/CIS/Stroke patients, and compare to healthy volunteers

Time frame: Baseline