A Study of CAR-T Cells in Subjects With Systemic Lupus Erythematosus

Inclusion Criteria: * Male or female, between 18 and 65 years old; * Diagnosed with SLE according to 2019 EULAR/ACR SLE classifications; * Positivity for ANA (titer≥1:80), and/or anti-dsDNA, and/or anti-Smith antibody at screening; * SLEDAI-2K≥8 points (with a clinical SLEDAI-2K≥6 points) ; * Patients who have used stable standard treatment regimen for at least 6 months in their medical history before screening, and their condition is still active for at least 2 months before screening. * Good organ functions; * Voluntary participates this trial and can comprehend and sign ICF. Exclusion Criteria: * Had or has active malignancy; * Had been subjected to treatment by CD19 targeted therapy or CAR-T therapy or any gene therapy; * Combined with other autoimmune disease that needs treatment; * Pregnant or lactating women; * Has other factors that deemed not suitable by investigator.