The present study is designed to explore the value of targeted puncture guided by PSMA PET/CT or mpMRI in the diagnosis of patients with low PSA and initial negative prostate biopsy
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
120
The patient will undergo pelvic non-contrast CT imaging. After co-registration of the CT images with 68Ga-PSMA PET/CT data at corresponding anatomical levels, a percutaneous gluteal approach will be utilized for CT-guided prostate biopsy.
The patient will undergo transrectal ultrasound (TRUS) prostate scanning. After co-registration and precise image fusion of TRUS findings with multiparametric MRI (mpMRI) data, a transperineal percutaneous approach will be employed to perform TRUS-guided prostate biopsy.
The patient will undergo systematic prostate biopsy under TRUS guidance.
Nanjing First Hospital
Nanjing, Jiangsu, China
Biospy outcome
Compare the diagnostic value (including sensitivity, specificity, NPV and PPV) between puncture methods and set up a diagnostic model.
Time frame: 12 months
Duration of puncture operation
Record the time required for each patient's puncture procedure
Time frame: 12 months
Patient's pain level
Based on VAS pain score
Time frame: 12 months
Blood loss
Bleeding volume during and after operation
Time frame: 12 months
Complication
Complications during and after the operation, including urethral injury, hematuria, and urinary tract infection, etc.
Time frame: 12 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.