The study team is conducting a study to see if Magnesium-L-Threonate (MgT) can help improve how well participants sleep and reduce pain after total joint replacement surgery
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
64
Participants will receive a daily 145 mg pill by mouth 30 minutes before going to sleep
Participants will receive two sugar pills daily by mouth 30 minutes before going to sleep
University of Miami Hospital
Miami, Florida, United States
RECRUITINGChange in Epsworth Sleepiness Score
Score ranging from 0-24 with higher scores indicating greater sleepiness.
Time frame: 2 weeks, 4 weeks, 6 weeks
Change in Pittsburgh Sleep Quality Index (PSQI)
The total score has a value between 0-21 and a high total score demonstrates a poor quality of sleep. A total PSQI score which is ≤5 indicates "good sleep", and a score which is \>5 indicates "poor sleep
Time frame: 2 weeks, 4 weeks, 6 weeks
Change in Morphine Milligram Equivalent Prescribed
Measured in milligram equivalents
Time frame: 2 weeks, 4 weeks, 6 weeks
Patient-reported outcome measured by Knee Injury and Osteoarthritis Outcome Score
The total score ranges from 0-100. Lowers scores indicate a healthier knee
Time frame: 6 weeks
Medication Compliance measured in number of days study medication taken
Medication compliance as measured by number of days taking study medication
Time frame: 6 weeks
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