This study will evaluate the effect of ISGLT2 (Dapagliflozin or Empalgliflozin), administered once daily in addition to standard of care treatments for non-diabetic patients with myocardial infarction (MI) treated with PCI, on hospitalization for heart failure, readmissions for acute coronary syndrome and all-cause mortality.
This is a single-center, prospective study in non-diabetic patients with acute coronary syndrome (ACS) (ST elevation (STEMI) or non-ST elevation (NSTEMI) with left ventricular systolic dysfunction (Defined as Ejection Fraction\<50% assessed by 2D Simson Bi-plane echocardiography) or evidence of acute de Novo heart failure. The study will assess the effect of dapagliflozin or empagliflozin versus placebo, administered once daily in addition to standard therapy, on HF hospitalizations, all-cause deaths and ACS readmissions.
Study Type
OBSERVATIONAL
Enrollment
450
Patients for whom we will prescribe ISGLT2
Mohammed VI university hospital oujda
OUDA, Morocco
Primary endpoints
Time to the first occurrence of any of the components of this composite: hospitalization for heart failure (HHF), Non fatal Myocardial infarction (MI) or Death from all causes
Time frame: 50 months
Secondary outcomes
Time to the first occurrence of a fatal or a non-fatal MI \[Time Frame: From admission visit (Day 0) up to approximately 4.2years\] Time to first hospitalisation for Heat failure \[Time Frame: From admission visit (Day 0) up to approximately 3 years\] Time to death of any cause \[Time Frame: From admission visit (Day 0) up to approximately 4.2 years\] Time to new onset of type 2 diabetes mellitus (T2DM) post discharge \[Time Frame: From admission (Day 0) up to approximately 4.2 years\] Time to new onset atrial fibrilation (AF) post discharge \[Time Frame: From admission visit (Day 0) up to approximately 4.2 years\]
Time frame: 50 months
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