The goal of this clinical trial is to investigate the impact of a 10-week moderate intensity interval walking training (MIIWT) program on kidney function markers in obese postmenopausal women. The main question it aims to answer is: Does MIIWT improve kidney function markers in this population? Researchers will compare MIIWT (designed to training group) to non-training intervention (designed to control group) to see if the training program works to improve kidney function markers. Participants in training group will: perform a 10-week MIIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.
The convergence of the obesity pandemic and the postmenopausal status is likely associated with renal function decline. Regular aerobic training have been shown to prevent adverse health outcomes in obese. The main purpose of this study was to evaluate changes in kidney function markers and white blood cell (WBC) subpopulations in obese postmenopausal women participating in moderate intensity interval walking training (MIIWT). A total of 36 obese postmenopausal women were randomized to MIIWT (CON, n=18) or control group (CON, n=18), four times a week for 10-week. The MIIWT consisted on 5 repetitions of walking for 6-min at 60-80% of the 6-min-walk-test-distance with 6-min of active recovery between repetitions. Before and after the MIIWT, body composition, kidney function markers (serum creatinine \[sCr\], blood urea nitrogen \[BUN\], serum uric acid \[sUA\] and Glomerular Filtration Rate \[GFR\] and white blood cells (WBC) count and its specific subpopulations (neutrophils \[NEU\], lymphocytes \[LYM\], monocytes \[MON\], eosinophils \[EOSI\] and basophils \[BASO\]) were assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
36
Moderate intensity intermittent walking training for a period of 10 weeks. The intensity of the training is 60 to 80% of 6MWTdistance. The frequency of the training is four times a week.
High Institute of Sports and Physical Education of Kef
Boulifa, Kef Governorate, Tunisia
serum creatinine
serum concentrations of creatinine (sCr) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
blood urea nitrogen
serum concentrations of blood urea nitrogen (BUN) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
serum uric acid
serum concentrations of uric acid (sUA) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
glomerular Filtration Rate
the glomerular Filtration Rate (GFR) has been computed using the Cockcroft formula, as follows: GFR (mL/min) = \[(140 - age) × weight ×0.85\]/(sCr× 72).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
white blood cells count
blood concentration of white blood cells (WBC) count were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany)
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
neutrophils
blood concentration of neutrophils (NEU) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
lymphocytes
blood concentrations of lymphocytes (LYM) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
monocytes
blood concentration of monocytes (MON) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
eosinophils
blood concentrations of eosinophils (EOSI) ) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
basophils
blood concentration of basophils (BASO) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany).
Time frame: At baseline and at week 11(after the ten weeks of the training intervention).
Body composition
Body composition were determined, with barefoot and lightly dressed subjects, using a stadiometer (Holtain Ltd., UK) and an electronic scale (Tanita BC-533, Tokyo, Japan).
Time frame: At baseline and after ten weeks of the training intervention.
6 min walking test
The 6-minute walk test was performed before and after the training intervention as an indicator of exercise capacity.
Time frame: At baseline and after ten weeks of the training intervention.
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