Cefixime Versus Benzathine Penicillin G in Treatment of Early Syphilis

Inclusion Criteria: 1. 18 years of age or older 2. Non-pregnant, non breastfeeding 3. Able to provide informed consent 4. Clinically or laboratory-confirmed primary, secondary or early latent syphilis with a positive rapid treponemal test and an RPR/VDRL titer equal to or greater than 1:8 5. Non-cephalosporin allergic 6. Non-penicillin allergic 7. Agree to be occasionally called by study staff to be reminded to take study drug 8. Willing to attend follow-up visits Exclusion Criteria: 1. Under 18 years of age 2. Pregnancy, breastfeeding 3. Prior history of syphilis in last two years 4. Allergy or contraindication to penicillin or cephalosporins (including allergy to cefixime) 5. Systemic antibiotic therapy in last two weeks 6. Previous enrollment in the study 7. Presenting a situation or condition that would not allow reliable study follow up (For example: frequent travel, alcohol abuse or substance misuse)