Study of Lipid Mediators in Chronic Postoperative Pain - LICP

Université Catholique de Louvain300 enrolled

Overview

This interventional prospective study aims firstly to investigate variations in lipid levels in blood samples and their potential relationship with the duration and/or intensity of post-operative pain. Secondly, it aims to investigate the activation of peripheral blood mononuclear cells and neutrophils in patient blood samples. The study will enrol women aged 18 years or older who have been newly diagnosed with primary invasive or non-invasive breast cancer requiring surgical removal of the tumour, with or without axillary surgery. The main objectives of the study are To assess whether there is an association between circulating levels of lipid mediators and chronicity (\> 3 months) of postoperative pain after breast cancer surgery. To assess whether circulating levels of lipid mediators can predict chronicity of postoperative pain in breast cancer surgery. To assess the existence of an association between resected tissue levels of lipid mediators and chronicity of postoperative pain in breast cancer surgery. To assess whether tissue levels of lipid mediators can predict chronicity of postoperative pain in breast cancer surgery.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

300

Conditions

Breast Cancer Female Postoperative Pain

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women older than 18 years * Newly diagnosed primary invasive or non-invasive breast cancer, requiring surgical excision of the tumor, with or without axillary surgery * Able to give informed consent Exclusion Criteria: * Men * Women aged less than 18 years * Pregnant women * History of major psychiatric disorders * Previous breast or axillary surgery, recurrent disease or detectable metastatic disease at the time of diagnosis * Unable to give informed consent

Outcomes

Primary Outcomes

Pain intensity

Pain intensity will be evaluated using a standardized questionnaire completed by participants at each medical consultation.

Time frame: Throughout the study, an average of 2 years

Pain duration

Pain duration will be evaluated using a standardized questionnaire completed by participants at each medical consultation.

Time frame: Throughout the study, an average of 2 years

Lipid Mediator Levels in Blood

Lipid mediator levels will be quantified in blood samples by LC-MS methods

Time frame: Throughout the study, an average of 2 years

Study of Lipid Mediators in Chronic Postoperative Pain - LICP

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts