The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.
Patients will be allocated to either propofol or sevoflurane group. Nociceptive event will be defined as long-lasting tetanic stimulation, square-wave, duration of 30 seconds , amplitude of 50mA, frequency of 50 Hz. analgesia nociception index value and hemodynamic parameters will be recorded 1-minute before and after nociceptive event.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
30
propofol anesthesia
sevoflurane anesthesia
analgesia nociception index change
analgesia nociception index value 1-minute before tetanic stimulation and 1-minute after tetanic stimulation
Time frame: During anesthesia period
Hemodynamic change
Blood pressure change 1 minute before tetanic stimuation and 1 minute after tetanic stimulation
Time frame: During anesthesia period
Hemodynamic change
Heart rate change before 1-minute before nociceptive stimuli and 1-minute after nociceptive stimuli
Time frame: During anesthesia period
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