Effect of Intraarticular Ozone, Prolotherapy or Dexmedetomidine in Pain Limitation in Knee Osteoarthritis

Tanta University60 enrolled

Overview

This study aimed to compare intraarticular ozone injection, prolotherapy, or dexmedetomidine effectiveness in knee osteoarthritis patients.

Osteoarthritis (OA) is a heterogeneous group of disorders of different etiologies with similar biological, morphological, and clinical manifestations and outcomes. The intraarticular injection has been recommended to alleviate the pain in the knee joint. Ozone therapy has long been used in the management of OA. Furthermore, it has been shown to not cause a significant inflammation process or cartilage degradation. Prolotherapy is a procedure where a natural irritant is injected into the soft tissue of an injured joint. Dexmedetomidine is a selective α2-adrenergic agonist with considerable sedative and analgesic actions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Intraarticular Ozone Prolotherapy Dexmedetomidine Pain Knee Osteoarthritis

Interventions

OzoneDRUG

Patients received intraarticular ozone injection.

Dextrose prolotherapyDRUG

Patients received intraarticular dextrose prolotherapy injection.

DexmedetomidineDRUG

Patients received intraarticular dexmedetomidine injection.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age from 30 to 65 years. * Both genders. * Patients diagnosed with stage 1-3 osteoarthritis according to the Kellgren-Lawrence Classification System (K-L). Exclusion Criteria: * Patient refusal. * History of knee trauma within the past month. * Rheumatic disease. * Pregnancy. * Any surgical intervention of the knee. * Severe cardiovascular disease. * Morbid obese patients (body mass index (BMI) of \>35 kg/m2). * Local infection at the site of injection. * Bleeding diathesis.

Locations (1)

Tanta University

Tanta, El-Gharbia, Egypt

Outcomes

Primary Outcomes

Analgesic requirement

Analgesic requirements for pain control after injection were recorded.

Time frame: 3 months after the procedure

Secondary Outcomes

Improvement of lifestyle

Improvement of lifestyle was assessed using the Western Ontario Mac Master Osteoarthritis Index (WOMAC-OI) scale. The Likert type of the WOMAC Persian version was employed in this paper. The Persian version is a dependable and uncomplicated procedure that provides five responses: extreme (4), severe (3), moderate (2), mild (1), and none (0). The patients' stiffness, pain, and functional restriction are all represented by the higher scores.

Time frame: 3 months after the procedure

Improvement of knee joint cartilage regeneration

Improvement of knee joint cartilage regeneration was assessed using the Kellgren-Lawrence Classification System (K-L). K-L: which categorize knee OA into four stages based on radiological findings: Grade 4 (severe): Marked joint space narrowing, large osteophytes, severe sclerosis, and definite deformity of bone ends. Grade 3 (moderate): Moderate multiple osteophytes, some sclerosis, definite joint space narrowing, and potential deformity of bone ends. Grade 2 (minimal): Definite osteophytes and potential joint space narrowing. Grade 1 (doubtful): Possible osteophytic lipping and doubtful joint space narrowing.

Time frame: 3 months after the procedure

Data from ClinicalTrials.gov

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