D Vitamin and Alveolar Macrophages in Idiopathic Pulmonal Fibrosis

University of Aarhus120 enrolled

Overview

The goal of this observational study is to gain deeper insights into human macrophages and vitamin D, and their interplay, within Idiopathic Pulmonary Fibrosis (IPF). The overall questions, it aims to answer, are the following: Do IPF patients suffer from systemic and local (pulmonary) insufficient levels of vitamin D? Do IPF patients suffer from pro-fibrotic and pro-inflammatory pulmonary macrophages?

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Idiopathic Pulmonary Fibrosis (IPF)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * A clinical diagnosis of IPF, non-IPF ILD or lung cancer * A signed informed consent Exclusion Criteria: * Do not speak Danish/Do not understand Danish

Locations (1)

Aarhus University Hospital, Denmark

Aarhus N, Denmark

RECRUITING

Outcomes

Primary Outcomes

Vitamin D status

Significant change in vitamin D levels in systemic (blood) and local (pulmonary) metabolism.

Time frame: At enrollment

Pulmonary macrophages

Significant change in alveolar macrophage phenotype

Time frame: At enrollment

Secondary Outcomes

Biomarker levels in blood and BAL samples

Significant change in levels of macrophage and inflammatory/fibrotic biomarkers

Time frame: At enrollment

Data from ClinicalTrials.gov

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