Impact of Rosuvastatin Doses on LDL Levels, CPK Levels and Aspartate Aminotransferase Levels

N/ACompletedNCT06910098

Central Park Medical College195 enrolled

Overview

Particpants were divided into groups based on doses of rosuvastatin and were assessed and for CPK, LDL and AST levels

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

195

Conditions

LDL - Low Density Lipoprotein Receptor Disorder Rosuvastatin

Interventions

RosuvastatinDRUG

a dose of 5mg were given and were compared for the cpk, ast and ldl levels

RosuvastatinDRUG

a dose of 10 mg were given and were compared for the cpk, ast and ldl levels

RosuvastatinDRUG

a dose of 20 mg were given and were compared for the cpk, ast and ldl levels

Eligibility

Sex: ALLMin age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: patients who were already on statins Exclusion Criteria: hereditary diseases including familial hypercholesterolemia and kidney diseases

Locations (1)

Central Park Teaching Hospital

Lahore, Pakistan

Outcomes

Primary Outcomes

impact of rosuvstatin over LDL, CPK and AST levels

Pre- and post intervention levels of fasting serum low-density lipoprotein (LDL) in mg/dL were recorded and were compared in all study groups for assessment of the impact of various doses of rosuvastatin.

Time frame: 12 weeks

impact of rosuvstatin over LDL, CPK and AST levels

Pre- and post-intervention levels of creatine phosphokinase (CPK) in mcg/L were recorded and were compared in all study groups for assessment of the impact of various doses of rosuvastatin in terms of rhabdomyolysis.

Time frame: 12 weeks

impact of rosuvstatin over LDL, CPK and AST levels

Pre- and post-intervention levels of Aspartate Aminotransferase (AST) in U/L were recorded and were compared in all study groups for assessment of the impact of various doses of rosuvastatin in terms of liver damage.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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