Assessment of Transcatheter Edge-to-Edge Repair in Atrial Functional Mitral Regurgitation (ATRIAL-MR)

Residual Mitral Regurgitation ≤1+

Rate of patients achieving residual mitral regurgitation ≤1+ measured by transthoracic echocardiography. Assessment of mitral regurgitation severity according to current guidelines (ESC/EACTS and ACC/AHA) for valvular heart disease.

Time frame: 12 months

All-cause mortality

Time frame: 12 months

Cardiovascular mortality

Time frame: 12 months

Heart failure related rehospitalization

Incidence of new-onset or worsening signs and symptoms of heart failure that required urgent therapy and resulted in hospitalization.

Time frame: 12 months

Unplanned mitral valve intervention

Incidence of unplanned surgical or transcatheter re-intervention, heart transplantation or left ventricular assist device implantation.

Time frame: 12 months

New York Heart Association (NYHA) class III or IV

Assessment of New York Heart Association (NYHA) classification stage (in- or outpatient), with the minimum of I (no symptoms) and the maximum of IV (dyspnea at rest), with higher values indicating worse functional capacity.

Time frame: 12 months

6 Minute Walking Distance

Time frame: 12 months