Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

University of Florida60 enrolled

Overview

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

We will test the hypotheses that DBS can facilitate split-belt walking adaptation with DBS ON compared with DBS OFF.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Parkinson Disease

Interventions

Deep Brain Stimulation (DBS)DEVICE

Patients will receive DBS in the clinically-optimized setting.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases; * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings; * Age between 18 - 80 years old per the FDA data sheet for PD DBS; * no dementia according to the clinical diagnostic criteria for PD dementia; * ambulatory without the use of walking aids, or another person's assistance. Exclusion Criteria: * other previous neurological surgery; * suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

Locations (1)

University of Florida

Gainesville, Florida, United States

RECRUITING

Outcomes

Primary Outcomes

Step length rate of adaptation

The rate of adaptation in step length asymmetry is estimated by fitting an exponential decay function to step length asymmetry over the first 100 strides in adaptation.

Time frame: 1 hour

Step length magnitude of adaptation

The magnitude of adaptation in step length asymmetry is estimated by fitting an exponential decay function to step length asymmetry over the first 100 strides in adaptation.

Time frame: 1 hour

Step length after-effects

The after-effect in step length asymmetry is calculated as the mean difference in step length asymmetry between the last 5 strides of baseline and the first 5 series of post-adaptation.

Time frame: 1 hour

Central Contacts

Julia Choi, Ph.D.

CONTACT

3522941720 juliachoi@ufl.edu

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.