Long-term Safety and Efficacy Evaluation of Lunsekimig in Adult Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Completed a Previous Lunsekimig CRSwNP Study

Change in SNOT-22 total score

The SNOT-22 is a 22-item health-related outcomes assessment. The 22-question SNOT-22 is scored as 0 (no problem) to 5 (problem as bad as it can be) with a total range from 0 to 110 (higher scores indicate poorer outcomes).

Time frame: From the parent study baseline to Week 52

Change in rhinosinusitis visual analog scale (VAS)

The VAS for rhinosinusitis is used to evaluate the total severity. The participant is asked to indicate along a 10 centimeter straight horizontal line (VAS) the answer to the question: "How troublesome are your symptoms of your rhinosinusitis". The VAS ranks from 0 (Not troublesome) to 10 (Worst thinkable troublesome) and is measured in centimeters

Time frame: From the parent study baseline to Week 52

Change in University of Pennsylvania Smell Identification Test (UPSIT) score

The UPSIT test is a rapid and easy-to-administer method to quantitatively assess human olfactory function. The test consists of four booklets, each containing 10 odorants with one odorant per page. Above each odorant strip is a multiple-choice question with four alternative words to describe the odor. Score depends on the amount of answers out of 40 possible correct answers.

Time frame: From the parent study baseline to Week 52

Serum lunsekimig concentrations

Time frame: From baseline to end of study (approximately 56 weeks)

Anti-drug antibodies (ADA) against lunsekimig

Time frame: From baseline to end of study (approximately 56 weeks)