This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days. The aim is to compare how effective each antibiotic is in improving symptoms after 2 days of treatment.
This randomized controlled trial will evaluate the effectiveness of two antibiotics-doxycycline (a tetracycline) and levofloxacin (a fluoroquinolone)-in the treatment of acute exacerbations of chronic obstructive pulmonary disease. Participants will be assigned to one of the two treatment groups and will receive either doxycycline 100 mg twice daily or levofloxacin 500 mg once daily for 5 days. The primary outcome is clinical cure. This will be evaluated 2 days after completion of antibiotic therapy, based on symptom resolution and laboratory markers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
188
Doxycycline will be given to COPD group 1
Levofloxacin given to copd patients
General hospital
Lahore, Pakistan
Clinical Cure Rate
1. A decrease in the respiratory rate by 20% from the baseline measurement. 2. Restoration of Oxygen saturation levels to within the range of 88-92% on room air. 3. CRP\<10ng/ml 4. decrease in sputum quantity 5. reduction in body temperature below 99•F 6. TLC \<11,000
Time frame: 7 days
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