Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.
Study Type
OBSERVATIONAL
Enrollment
20
Ultrasound measures: contrast enhanced ultrasound (CEUS) of the kidney, venous excess ultrasound (VExUS), echocardiography
Sublingual incident dark field (IDF) videomicroscopy
Continuous urinary oxygen tension
King's College Hospital
London, United Kingdom
RECRUITINGCortical mean transit time (mTT) measured in seconds
Contrast enhanced ultrasound measure of renal cortical tissue blood flow
Time frame: Measured at enrollment, +24 hours and + 48 hours
Cortical perfusion index (PI) measured in arbitrary units
Contrast enhanced ultrasound measures of renal cortical tissue blood flow
Time frame: Measured at enrollment, +24 hours and + 48 hours
Cortical wash in rate (WiR) measured in arbitrary units
Contrast enhanced ultrasound measures of renal cortical tissue blood flow
Time frame: Measured at enrollment, +24 hours and + 48 hours
Urinary oxygen tension (pO2) across 24 hours study period measured in millimetres of mercury (mmHg)
Mean urinary pO2
Time frame: Across 48 hour study period
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