Coronary chronic total occlusions (CTO) present a significant challenge in the field of interventional cardiology. These complex lesions, characterized by complete blockage of a coronary artery for a prolonged duration, often require specialized techniques and strategies to achieve successful revascularization.
Using this consortium, we will establish a multicenter cohort to evaluate the clinical parameters, angiographic characteristics, interventional techniques, and clinical outcomes involved in coronary CTO intervention. 3 subprojects are listed here. Subproject 1 intends to develop a novel algorithm integrating antegrade and retrograde scoring system to optimize the CTO intervention and determine the optimal timing for primary retrograde approach. Current algorithm for CTO intervention. Subproject 2 aims to examine the strategies and outcomes of CTO involving bifurcations. Bifurcation CTO lesions present unique challenges due to their complex anatomy. Opening of the main vessel while preserving important branches is crucial for ensuring favorable long-term clinical prognosis. This subproject will investigate different strategies and devices employed in bifurcation CTO PCI to assess their efficacy and safety outcomes. Subproject 3 investigates the treatment strategies for right coronary artery (RCA) CTOs with concomitant left main disease, which present a unique and intricate scenario, requiring careful consideration of revascularization strategies.
Study Type
OBSERVATIONAL
Enrollment
5,000
Coronary CTO was identified by coronary angiography, and its revascularization was attempted by either antegrade, retrograde or both approach.
Chang Gung Memorial Hospital
New Taipei City, Taiwan
RECRUITINGNational Taiwan University Hospital
Taipei, Taiwan
RECRUITINGTaipei Veterans General Hospital
Taipei, Taiwan
RECRUITINGNumber of participants with technical success of CTO revascularization
Successful CTO recanalization with \<20% residual stenosis within the treated segment and restoration of Thrombolysis in Myocardial Infarction grade 3 antegrade flow, without side branch loss
Time frame: 1 day
Number of participants with collateral channel tracking success
retrograde guidewire crossing the CC to reach the distal cap of CTO segment.
Time frame: 1 day
Number of participants with major adverse cerebral cardiovascular events
Death, CV death, myocardial infarction, stroke, repeat revascularization
Time frame: 5 years
Number of participants with periprocedural myocardial infarction
Confirmed by
Time frame: 1 day
Number of participants with periprocedural complications
Periprocedural myocardial infarction, vessel perforation, stroke, urgent or emergent revascularization
Time frame: 1 day
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