Effect of CGF on Postoperative Pain After Third Molar Surgery

Ege University49 enrolled

Overview

The purpose of this study is to evaluate the effects of concentrated growth factor (CGF) on pain after bilateral impacted third molar surgery and to determine its contribution to the healing process. The main question it aims to answer is: Is CGF effective on reducing the pain in impacted third molar surgery? Researchers compare the pain on the CGF-applied and CGF free sides after impacted third molar surgery. Postoperative pain is assessed using the Visual Analogue Scale. TThe postoperative outcomes including pain are clinically assessed at different-time intervals (1-7 days).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Oral Complication

Interventions

Concentrated Growth FactorOTHER

Bilaterally impacted third molar of the patients are removed surgically and concentrated growth factor is placed in one of the extraction sockets.

non-CGFOTHER

The other extraction socket is left empty for control purposes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted wisdom teeth in the mandible, regardless of gender * Patients without any systemic disease * Patients who have been informed about the duration, purpose and requirements of the study and who have signed the informed consent form voluntarily. Exclusion Criteria: * Having a disease affecting general health that requires the application of prophylactic antimicrobial agents * Having a systemic viral, fungal or bacterial infection * Patients with acute or chronic maxillary sinusitis * Suspected or diagnosed pregnancy and nursing mothers * Patients with heart and vascular diseases * Patients with liver disease, haematological disease and neoplastic disease * Patients who have recently received anti-inflammatory therapy * Patients with chronic medication use (antihistamines, NSAIDs, steroids and antidepressants) * Patients predisposed to psychotic or psychopathic tendencies * Patients with rheumatic diseases, blood diseases, diabetes mellitus * Patients at cardiological risk of infective endocarditis * Patients under antibiotic pressure

Locations (1)

Ege University Faculty of Dentistry

Izmir, Bornova, Turkey (Türkiye)

Outcomes

Primary Outcomes

Postoperative pain on CGF-applied and CGF free sides in bilateral impacted third molar surgery

The primary outcome measure is postoperative pain on CGF-applied and CGF free sides in bilateral impacted third molar surgery. Postoperative pain is assessed using the Visual Analogue Scale (VAS). Patients are asked to mark the pain they felt on the scale (10 cm long line) on the (1-7) days after the operation. The end of the line indicates unbearable pain, the beginning indicates no pain.

Time frame: The postoperative outcomes including pain are clinically assessed at different-time intervals (1st, 2nd, 3rd, 4th, 5th, 6th and 7th days).

Data from ClinicalTrials.gov

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