Chronic cough (\>8 weeks in duration) affects 5-12% of the global population, and is associated with considerable health status impairment and comorbidities. Currently, there are validated severity and impact outcome measures whilst objective measures with cough frequency monitoring is not available in routine clinical practice. Unlike other chronic respiratory diseases, namely asthma, there are no validated dedicated tools to assess the control of cough as a disease. This study aims to develop a validated patient-focused tool to assess the control of cough, which may be useful to evaluate the benefit and value of treatments in both clinical and research settings.
This study will involve 3 phases: * Phase 1: Literature review. Review of currently available validated tools to assess control in respiratory diseases. * Phase 2: Development of Cough Control Questionnaire (CCQ). Patient focus groups will aid development of a conceptual framework of cough control and ensure content validity through qualitative research methods including thematic analysis. Expert panel review of cough control framework will also be undertaken. CCQ item development will be grounded in patient focus groups and expert review findings, and reviewed through cognitive debrief with patients. * Phase 3: Validation of CCQ. Prospective consecutive patients with chronic cough will complete CCQ, cough severity assessments and health status assessments. Patients will be invited to undergo objective cough frequency monitoring and cough challenge testing.
Study Type
OBSERVATIONAL
Enrollment
100
Completion of new questionnaire in addition to other patient reported outcome measures that measure cough severity and cough-related quality of life.
Semi-structured focus group interviews for patients with refractory chronic cough
Cough monitoring and cough sensitivity testing.
King's College Hospital
London, United Kingdom
RECRUITINGA questionnaire to assess cough control
The primary aim of the study is to develop and validate a cough control questionnaire which accurately reflects the nature of cough control.
Time frame: 2 weeks
Cough severity
Assessed using dedicated patient reported outcome measures. Correlations with CCQ will be assessed.
Time frame: 2 weeks
Cough-related quality of life and health status
Assessed using dedicated patient reported outcome measures. Correlations with CCQ will be assessed.
Time frame: 2 weeks
Cough frequency
Cough frequency (Coughs/24 hours) will be assessed at visits using cough monitors and correlations with CCQ will be assessed.
Time frame: 2 weeks
Cough reflex testing
Capsaicin concentration for C2 and C5 (to elicit 2, and 5 coughs respectively) will be assessed in a subset of patients. Correlations with CCQ will be assessed.
Time frame: 2 weeks
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