Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis

N/AActive Not RecruitingNCT06920849

Medical University of Bialystok40 enrolled

Overview

Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.

Forty subjects diagnosed with periodontitis were randomly divided into two groups. In the test group, SRP was performed with the subsequent application of iPRF into periodontal pockets, while in the control group SRP was performed alone. Clinical examination was performed before and 1, 3 and 6 months after treatment. For inflammation mediators levels determination in GCF samples ELISA method will be used.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Periodontal Disease Periodontitis

Interventions

SRP+iPRFBIOLOGICAL

SRP (scaling and root planing) with iPRF (injectable platelet-rich fibrin)

SRPPROCEDURE

SRP (scaling and root planing)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * clinical and radiological features of periodontitis in stage II, III or IV * presence of at least 4 teeth and at least 2 pockets (localized not on the same tooth) with a depth of at least 5 mm in each quadrant Exclusion Criteria: * periodontal treatment within 3 months prior to the study; * antibiotic therapy within 3 months prior to the study; * smoking; presence of systemic diseases affecting periodontal healing, i.e.: immunosuppressive diseases, diabetes, osteoporosis, AIDS, hypertension treated with calcium channel blockers; * use of steroids or other immunosuppressive drugs; * coagulation disorders and use of drugs affecting its mechanisms; * pregnant and breastfeeding women

Locations (1)

Department of Integrated Dentistry, Medical University of Białystok

Bialystok, Poland

Outcomes

Primary Outcomes

Assessment of the influence of injectable platelet-rich fibrin on the clinical parameters in non-surgical treatment of periodontitis.

PD (Pocket Depth) from the gingival margin to the bottom of the sulcus, measured in mm

Time frame: up to 6 months after treatment procedure

Secondary Outcomes

Assessment of the influence of injectable platelet-rich fibrin on the levels of inflammation mediators in the GCF in non-surgical treatment of periodontitis.

Inflammation mediators level in GCF will be determined by the immunoenzymatic method ELISA (Enzyme - Linked Immunosorbent Assay) with the use of commercial kits.

Time frame: up to 3 months after treatment procedure

Data from ClinicalTrials.gov

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