The goal of this observational study is to learn about the effects of early-life adversity (ELA) on the composition of children's microbiome and on their psychosocial functioning. The main questions it aims to answer are: * Do children who have experienced ELA have lower gut microbial diversity and/or an altered gut microbial composition? * Do these microbiome alterations correlate with adverse neurodevelopmental outcomes, including increased levels of stress, social and/or affective problems?
Study Type
OBSERVATIONAL
Enrollment
50
Completion of questionnaires: * FFQ (Food Frequency Questionnaire) - completed by child * KIDSCREEN-10 - completed by child * CRIES-13 (Child Revised Impact of Events Scale) - completed by parents/guardian and child * CTES (Childhood Trust Events Survey) - completed by parents/guardian * RCADS-25 (Revised Children's Anxiety and Depression Scale) - completed by parents/guardian and child Child psychiatric screening using SCID-5-Junior - semi-structured interview conducted with child and parent(s)/guardian Faecal sample analysis: * Beta-diversity (UniFrac and Bray-Curtis distance index) * Firmicutes/Bacteroidetes ratio * Abundance of Prevotella, Lactobacillaceae, Bifidobacteriacae and Lachnospiraceae * Short-chain fatty acid metabolites
UZ Brussel
Jette, Brussels Capital, Belgium
Global mental wellbeing
KIDSCREEN-10 total score
Time frame: Assessment at enrollment
Microbiomial diversity
Gut microbiomial beta-diversity, based on UniFrac and Bray-Curtis distance index
Time frame: Assessment based on single stool sample, within 4 weeks after enrollment
Post-traumatic stress symptoms
CRIES-13 (Child Revised Impact of Events Scale) total scores, based on parent version and based on child version
Time frame: Assessment at enrollment
Anxiety and depression symptoms
RCADS-25 (Revised Children's Anxiety and Depression Scale) total scores, based on parent version and child version
Time frame: Assessment at enrollment
Firmicutes/Bacteroidetes ratio
Gut microbiomial Firmicutes/Bacteroidetes ratio
Time frame: Assessment based on single stool sample, within 4 weeks after enrollment
Gut microbiomial composition
Gut microbiomial abundance of Prevotella, Lactobacillaceae, Bifidobacteriacae and Lachnospiraceae
Time frame: Assessment based on single stool sample, within 4 weeks after enrollment
Short-chain fatty acid metabolites
Gut microbiomial short-chain fatty acid metabolites
Time frame: Assessment based on single stool sample, within 4 weeks after enrollment
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