* To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients. * To evaluate the short-term outcomes of those patients.
Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes . Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI . The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease . Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .
Study Type
OBSERVATIONAL
Enrollment
290
* CBC * Liver function test * kidney function test (serum creatinine, BUN, eGFR (EPI equation and MDRD equation) , * Prothrombin time and concentration, INR, * Serum electrolytes * Urine analysis.
Al-Raghi liver hospital
Asyut, Assuit, Egypt
In-hospital mortality
Mortality during hospital stay
Time frame: Through the study completion , average 6 months
Phenotypes of acute kidney injury across geographic areas
Characteristics of acute kidney injury (clinical type and stage)
Time frame: Baseline ( at admission ), then through the study completion, average 6 months
28-day mortality
Mortality at 28 days
Time frame: 28 days
Resolution of AKI
Resolution of AKI will be defined as return of serum creatinine to a value within 0.3 mg/di (26.5 mmol/L) of the baseline value. Partial response will be defined as regression of AKI to a lower stage with a reduction of serum creatinine to ≥0.3 mg/d\| (26.5 mmol/L) above the baseline value
Time frame: Hospital stay (up to 90 days)
Development of CKD
Chronic kidney disease will be defined as an estimated glomerular filtration rate \<60 ml/min ml/min/1.73 m2 for \>3 months. The Modification of Diet in Renal Disease equation will be used for estimating glomerular filtration rate
Time frame: 90 days
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