The goal of this observational study is to learn about the influence of Corona Virus Disease 2019 on obstetric outcome and offspring development.
The main questions it aims to answer are: * Collect the information about Corona Virus Disease 2019 infection and medication of pregnant women to establish a birth cohort, and analyze the correlation between Corona Virus Disease 2019 infection during pregnancy and adverse pregnancy outcomes and birth outcomes. * The offspring born in this cohort were followed up to analyze the effects of Corona Virus Disease 2019 infection during pregnancy on the nervous system development of the offspring. Researchers will compare Corona Virus Disease 2019 infection group and uninfected group during pregnancy to see if Corona Virus Disease 2019 infection has adverse effects on pregnant women and their offspring.
Study Type
OBSERVATIONAL
Enrollment
1,000
The Second Hospital of Shandong University
Jinan, Shandong, China
RECRUITINGJinan Maternity and Child Health Care Hospital
Jinan, China
RECRUITINGQianfoshan Hospital
Jinan, China
RECRUITINGMeasure the developmental outcomes of the nervous system using the Gesell Development Plan (GDS) or the 0-6-year-old Child Development Scale (DST).
GDS mainly diagnoses four abilities: motor ability, object ability, speech ability, and human ability,. Thus, the development quotient of four aspects can be obtained. If the development quotient is below 65-75, it indicates serious backwardness. The DST assessment includes five functional areas: gross motor, fine motor, language, adaptability, and social behavior, to obtain developmental quotient, which is used to measure the developmental behavior of children and evaluate their level of development. A score above 130 indicates excellent performance, and a score below 70 indicates intellectual development disorder.
Time frame: From 6 months of birth to completion of the GDS measurement, the assessment is up to 6 months
Pregnancy complications or comorbidities
Obtain relevant information from medical records. Pregnancy complications refer to non pregnancy related diseases that occur before or during pregnancy, while pregnancy complications refer to any diseases that coexist with pregnancy.
Time frame: Starting prenatal examination until discharge,the evaluation take up to 10 months
Obtain neonatal outcomes.
Obtain neonatal outcomes from neonatal records, including macrosomia, neonatal asphyxia, fetal distress, low birth weight infants, and deformed infants.
Time frame: The evaluation period from birth to discharge is up to 1 week
Comprehensive results of COVID-19 infection during pregnancy
Through questionnaires, medical records and test sheets, The investigators can get whether the pregnant women have been infected with COVID-19 during pregnancy, the time of infection, pregnancy weeks, symptoms, etc.
Time frame: Baseline data were obtained when participants were enrolled in the study and assessed for up to 1 years
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Qilu Hospital of Shandong University
Jinan, China
RECRUITINGShandong Provincial Maternity and Child Health Care Hospital
Jinan, China
RECRUITINGDelivery method
Natural delivery, vaginal surgery, or curettage.
Time frame: The evaluation period from admission to delivery to discharge is up to 1 week
Estimation of bleeding volume
Total amount of bleeding during or 24 hours postpartum.
Time frame: The evaluation period from admission to delivery to discharge is up to 1 week