Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines

Inclusion Criteria: * Between the ages of 18 and 60; * Generally healthy by self-report; * All races/ethnicities, both men and women; * Able to provide informed consent; * Able to attend repeated visits to Monell for sensory testing; * Willing to follow instructions (e.g., refrain from eating or drinking for at least 1 hour before sessions, willing to remain on site for one hour after tasting an API that the participant has never tasted before). - Exclusion Criteria: * Under 18 or over 60; * Pregnant, nursing, or plans to become pregnant; * Unable to provide consent (including limited ability to understand written and spoken English); * Tobacco, vape, marijuana, or tetrahydrocannabinol cartridge users. We will accept people who have used tobacco or marijuana products on occasion, but not regular users; * Known drug or food allergies of any kind; * Diabetes or other metabolic disorder; * Liver issues of any kind, including viral hepatitis; * Kidney issues of any kind; * Other chronic illness, including cardiovascular, neurological, immune disorders, or any other serious acute or chronic condition * Dentures or other major dental implants; * Condition affecting the oral cavity, including dry mouth, burning mouth syndrome, active sores or blisters, geographic tongue, or other disorders * Current infection or cold, flu, or infection with SARS-CoV-2 within the last four weeks; * Unable to taste or smell * Daily use, or use within the last four weeks, of either prescription or over-the-counter medications (except for birth control) * History of tuberculosis (including latent tuberculosis), positive skin or other tuberculosis test at any time in the past, birth in or residence in a country with high tuberculosis rates, known contact with someone who is tuberculosis positive * HIV infection