The Investigation of Predicting Mortality and Morbidity in Patients Admitted to Intensive Care Unit With Thoracic Trauma Using Selected Biomarkers and Parameters

Suleyman Demirel University50 enrolled

Overview

This prospective study aimed to predict morbidity and mortality after thoracic trauma in intensive care unit evaluated clinical and biochemical data of 50 intensive care unit patients. The research examined demographic factors such as gender, age, and smoking status, trauma scoring systems like ISS and RTS as well as biomarkers such as Surfactant-d and oxygenation parameters including the ROX index, PaO₂/FiO₂ ratio and FiO₂.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Thorax Traumas

Interventions

blood samplingDIAGNOSTIC_TEST

blood samples obtained for 3 different days, limited to 5cc

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with thoracic trauma between the ages of 18-85 * Patients who have been monitored in intensive care for at least 1 week Exclusion Criteria: * Being outside the age range of 18-85 * Pregnant patients * Patients whose intensive care follow-up lasted less than 1 week * Patients who do not want to be included in the study * Patients with a lung malignancy diagnosis before admission

Locations (1)

Suleyman Demirel University

Isparta, Turkey (Türkiye)

Outcomes

Primary Outcomes

Mortality Prediction Using ROX Index in Thoracic Trauma Patients

To evaluate the predictive ability of the ROX index (unit: cmH₂O/L/s) for mortality in thoracic trauma patients. ROX index values were recorded at 1st, 3rd, and 7th days of hospitalization using standard clinical monitoring and ventilatory support parameters. Trends were analyzed in relation to survival outcomes.

Time frame: Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.

Mortality Prediction Using SP-D Levels in Thoracic Trauma Patients

To assess the prognostic value of Surfactant Protein D (SP-D) levels (unit: ng/mL) for mortality prediction in thoracic trauma patients. SP-D levels were measured using an ELISA assay (Elabscience® Human Pulmonary Surfactant-associated Protein-D ELISA Kit) at 1st, 3rd, and 7th days to evaluate trends and correlations with survival outcomes.

Time frame: Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.

Secondary Outcomes

Predictive Value of APACHE II Score in Mortality

To analyze the effectiveness of the APACHE II score (range: 0-71; higher scores indicate worse outcomes) in predicting mortality in thoracic trauma patients. APACHE II scores were calculated based on clinical and laboratory parameters, including vital signs, blood gas values, and organ dysfunction markers at 1st, 3rd, and 7th days.

Time frame: Measurements taken on day 1, day 3, and day 7 of hospitalization.

Predictive Value of SOFA Score in Mortality

To evaluate the prognostic accuracy of the Sequential Organ Failure Assessment (SOFA) score (range: 0-24; higher scores indicate worse outcomes) in thoracic trauma patients. SOFA scores were determined based on respiratory, cardiovascular, hepatic, coagulation, renal, and neurological functions at 1st, 3rd, and 7th days.

Time frame: Measurements taken on day 1, day 3, and day 7 of hospitalization.

Data from ClinicalTrials.gov

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