Effectiveness of Midodrine as an Adjuvant to Norepinephrine in Weaning Critically Ill Patients From Vasopressors

Inclusion Criteria: * Patients with refractory hypotension on an intravenous vasopressor for more than 24 h but deemed clinically stable. * Patients on noradrenaline support \<10 μg/min Exclusion Criteria: * Known allergy to midodrine. * Severe shock state, as evidenced by multiple vasopressor infusions or high vasopressor requirement (i.e. noradrenaline \>10 μg/min) * Patients with severe organic heart disease (e.g., heart failure, sever aortic stenosis), pregnancy, thyrotoxicosis or pheochromocytoma. * Those with no enteral route available.