Effect of the Anticholinergic Drug Burden on Postoperative Delirium in Elderly Chinese Patients: A Nested Case-Control Study

Hao Li10,536 enrolled

Overview

This study aims to investigate the association between preoperative anticholinergic drugs burden and postoperative delirium in elderly Chinese patients.

Study Type

OBSERVATIONAL

Enrollment

10,536

Conditions

Delirium - Postoperative

Eligibility

Sex: ALLMin age: 65 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients over 65 years; Undergoing general anesthesia; Inpatients who had surgery between Aprill 1, 2020 and Aprill 1, 2022. Exclusion Criteria: * ASA grade V; preoperative Mini-Mental State Examination (MMSE) score \<24;history of neurological disorders (such as cerebrovascular disease or dementia); emergency surgeries; operative duration ≤30 minutes, and cases with \>5% missing data.

Locations (1)

First Medical Center of Chinese PLA General Hospital

Beijing, China

Outcomes

Primary Outcomes

postoperative delirium

Time frame: 7 days after surgery

Data from ClinicalTrials.gov

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