The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry index (COx) and hemoglobin volume reactivity index (HVx). The main question it aims to answer is: Whether optimal perfusion pressure is dynamic and changes with time in patients with SAH, and that autoregulation is disrupted in patients during the course of SAH, contributing to delayed cerebral ischemia (DCI).
Study Type
OBSERVATIONAL
Enrollment
120
Near-Infrared Spectroscopy (NIRS) monitors, provided by Edwards Lifesciences, is a monitoring technique. It will be connected to consented patients, automatically capturing brain oxygen as waveform output, and stored in Sickbay system. The NIRS is a non-invasive monitoring method, in which adhesive pads will be applied to forehead. 4 hours continuous monitoring will be recorded on day 1 after SAH (or on presence to NICU), then every three days from day 3 to day 14 (within the DCI window), to 1 to 2 recordings from day 15 to day 21.
The University of Alabama at Birmingham
Birmingham, Alabama, United States
Change in Lower Limit of Autoregulation (LLA)
Successful calculations of moving Lower Limit of Autoregulation (LLA) for all three algorithms
Time frame: 21 days
Change of delayed cerebral ischemia (DCI) to the average LLA
Correlation of clinical course of delayed cerebral ischemia (DCI) to average LLA
Time frame: 21 days
Change in time under LLA
Correlation in time under LLA
Time frame: 21 days
Change in dose under LLA
Correlation in dose under LLA
Time frame: 21 days
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