The present study investigates the postprandial role of endogenous glucose-dependent insulinotropic polypeptide (GIP) on cardiovascular haemodynamics, hormone responses, and hypotensive symptoms during a tilt test.
The study is an exploratory, randomised, placebo-controlled, double-blinded crossover study comprising four experimental days. Each experimental day consists of a mixed meal test or drinking water, a double-blinded continuous infusion of GIP(3-30)NH2 or placebo or GIP(1-42) or placebo, and three tilt tests. Sixteen healthy men and women will be included in the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
16
Selective antagonist of the GIPR, GIP(3-30)NH2
Placebo (NaCl 0,9%)
Agonist of the GIPR, GIP(1-42)
Center for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark
NOT_YET_RECRUITINGCenter for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark
RECRUITINGPostprandial systolic blood pressure change (delta SBP)
The mean difference between postprandial systolic blood pressure-change (delta SBP) during tilt test following infusion of GIP(3-30)NH2 compared to infusion of placebo.
Time frame: From -35 to 50 minutes
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