High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only \~5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2: Define changes in eGFR andalbuminuria after 3 months of IMST vs. sham in Y-T2D, 3: Interrogate mechanisms of IMST by translational assessments of NO bioavailability, endothelial NO synthase (eNOS) activation, and ROS/oxidative stress, and determine the role of circulating factors.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
90
A novel form of physical training that uses the diaphragm and accessory respiratory muscles to repeatedly inhale against resistance using a handheld device, generating large negative intrathoracic pressures. The device can be set to different levels of resistance, meaning the intervention and sham groups will undergo the same training, but at 75% and 15% of their maximal inspiratory pressure respectively.
The same training regiment but at much lower resistance, offering little to strength training impact.
Seattle Children's Hospital
Seattle, Washington, United States
RECRUITINGUniversity of Washington Medicine Diabetes Institute
Seattle, Washington, United States
NOT_YET_RECRUITINGSystolic Blood Pressure
Measures of casual clinic and 24-hour ambulatory blood pressure monitoring
Time frame: 3 months
Endothelial function
Measured by brachial artery flow-mediated dilation and endothelial cell collection and analysis.
Time frame: 3 months
Arterial stiffness
Measured by carotid-femoral pulse-wave velocity and carotid-radial pulse-wave analysis using a SphygmoCor.
Time frame: 3 months
Kidney Function
Measured by estimated glomerular filtration rate and albuminuria assessments
Time frame: 3 months
Body Composition
Measured by BIS (Bioimpedance spectroscopy)
Time frame: 3 months
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