the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome

Phase 2RecruitingNCT06937645

Al-Nahrain University120 enrolled

Overview

Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval. endometrial receptivity parameters, including the subendometrial vasculature indices were measured before and after the intervention for purpose of studying the effect of hyaluronic acid on improvement of the endometrial receptivity and subsequently the pregnancy outcome

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

120

Conditions

Infertile Patients

Interventions

Hyaluronic Acid (HA)DRUG

hyaluronic acid PRP preparation used to wash the endometrium on the day of oocytes retrieval

platlet rich plasma (PRP)DRUG

PRP preparation used to wash the uterine cavity on the day of oocytes retrieval

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile females aged 18-40 years. * Infertile females scheduled for GnRH antagonist protocol of fresh ICSI cycle. * Females use dual stimulation (GnRH agonist plus Ovetrelle) for ovulation triggering. Exclusion Criteria: * Infertile females diagnosed as a poor responder. * Infertile females diagnosed with uterine pathology. * Infertile females who are scheduled for a frozen ICSI cycle. * Infertile females diagnosed with endocrine diseases like thyroid disease, diabetes mellitus, and hyperprolactinemia. * Infertile females diagnosed with thrombocytopenia.

Locations (1)

high institute for infertility diagnosis and ARTS

AL-Kadimya, Baghdad Governorate, Iraq

RECRUITING

Outcomes

Primary Outcomes

measuring the value of resistance index (RI) of the sub-endometrial blood vessels

We will measure the value of the resistance index (RI) using the transvaginal ultrasound Doppler study. For each patient, RI will be measured twice: the first measure will be done before the intervention on the day of oocyte retrieval, and the second measure will be performed after the intervention on the day of embryo transfer. we will calculate RI according to the following equation Resistance index (RI)= \[Peak Systolic Velocity (PSV) cm/sec - End Diastolic Velocity (EDV) cm/sec \] / Peak Systolic Velocity (PSV) cm/sec Then a statistical comparison will be made to evaluate the difference between the two readings to study the effect of the intervention on the measured parameter for each group.

Time frame: for each participant twice measure will be done for (RI). The first measure will be performed on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.

measuring the value of sub- endometrial vessels pulsatile index (PI)

We will measure the value of the pulsatile index (PI) using the transvaginal ultrasound Doppler study. PI will be measured twice for each patient: once before the oocyte retrieval intervention and once after the embryo transfer intervention. then PI will be calculated according to the following equation Pulsatility Index (PI) = \[Peak Systolic Velocity (PSV) cm/sec - end Diastolic Velocity (EDV) cm/sec \] / Mean Velocity (MV) cm/sec Then a statistical comparison will be made to evaluate the difference between the two readings to study the effect of the intervention on the measured parameter for each group.

Time frame: for each participant twice measure will be done for PI. The first measure is on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.

measuring the value of peak systolic to end diastolic ratio (S/D) of the sub-endometrial blood vessels

We will measure the value of the peak systolic to end diastolic ratio (S/D) using the transvaginal ultrasound Doppler study. For each patient, S/D will be measured twice: the first measure will be done before the intervention on the day of oocyte retrieval, and the second measure will be performed after the intervention on the day of embryo transfer. S/D will be calculated according to the following equation S/D= Peak Systolic Velocity (PSV) cm/sec /End Diastolic Velocity (ED) cm/sec Then a statistical comparison will be made to evaluate the difference between the two readings to study the effect of the intervention on the measured parameter for each group.