Photodynamic Therapy for Glioblastoma Multiforme Based on Metaverse and Yellow Fluorescence

Inclusion Criteria: Pathologically confirmed primary focal GBM; Recurrent GBM(single or satellite lesions); Multiple (multiple germinal centers)GBM. Exclusion Criteria: * Photosensitizer allergy. * Severe coagulation disorder. * Patients with severe cardiovascular and cerebrovascular diseases, especially patients in the acute stage. * Multiple organ failure, end-stage patients. ⑤ Pregnant women: Photofrin is considered a class C pregnancy risk (toxic, non-teratogenic) drug with non-dialysis properties. Non-gbm diagnosis: Patients with other types of brain tumors or diseases. 7 Do not agree to informed consent: patients who are unwilling to sign informed consent or do not agree to participate in the study.