Effect of YAP1-inhibition in Surgical Wounds.

Inclusion Criteria: * Willing and able to provide informed consent as documented by signature * Age is \>/= 18 years and \< 56 years (differently said: starting from the 18th birthday to completion of their 55 years) * Indication for a safety margin excision (5 mm laterally) due to melanoma in situ or severe dysplastic nevi previously completely excised * Length of initial scar from 15 mm to 50 mm * The initial lesion was excised on the back (to ensure that all patients undergo their safety margin excision within the internationally accepted timeframe, we will also accept patients requiring the procedure at another anatomical site if a particular batch cannot be filled within 4 weeks of its first patient's enrollment) Exclusion Criteria: * Clinical adenopathy (cervical, axillar, inguinal) defined as a lymph node of more than 1 cm diameter * Melanoma in situ of lentigo maligna or acral lentiginous type * Head and neck location * Diameter of initial lesion above or equal to 3 cm * Known and documented hypersensitivity to Verteporfin or to any of its excipients: lactose monohydrate, egg phosphatidylglycerol (to simplify we will exclude patients with known and documented allergy to egg protein), dimyristoyl phosphatidylcholine, ascorbyl palmitate, butylated hydroxytoluene (E321) * Porphyria * Moderate hepatic dysfunction referred to as any of the following: AST \>1.2x upper normal range, ALT \>1.2x upper normal range, decreased albumin level, prolongation of PT * Biliary obstruction referred to as any of the following: ALP \>1.2x upper normal range, GGT \>1.2x upper normal range, anormal bilirubin level * Pregnancy referred to as: positive beta-hCG blood test * Breast-feeding * Planned pregnancy in the next 6 months * History of either one of the following: keloids, scleroderma, morphea, lupus erythematosus, nephrogenic systemic fibrosis, graft-versus-host disease, lichen sclerosus, eosinophilic fasciitis, Ehlers-Danlos syndrome, cutis laxa, Marfan syndrome, or pseudoxanthoma elasticum