Effect of Mild Therapeutic Hypothermia on the Doses of Vasopressors and Inotropes in Cardiogenic Shock Complicating Acute Myocardial Infarction

Tanta University60 enrolled

Overview

The study aimed to assess the effects of mild therapeutic hypothermia (MTH) on vasopressors and inotropes in patients with cardiogenic shock (CS) due to acute myocardial infarction (AMI).

Cardiogenic shock (CS) is a condition characterized by a severe lack of blood flow to vital organs caused by primary malfunction of the heart, as described by the European Society of Cardiology (ESC) and the American Heart Association (AHA). Acute myocardial infarction (AMI) is a prevalent etiology of CS, constituting a minimum of 30% of the instances. 50% of CS cases manifest upon hospital admission, whereas the remaining 50% occur after hospital admission.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Mild Therapeutic Hypothermia Cardiogenic Shock Acute Myocardial Infarction Vasopressors Inotropes

Interventions

Mild therapeutic hypothermiaDRUG

Patients received mild therapeutic hypothermia (MTH) to 33°C for 24-36 h

Eligibility

Sex: ALLMin age: 50 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age from 50 to 70 years. * Both sexes. * Cardiogenic shock post AMI defined by systolic blood pressure \<90 mm Hg for \>30 minutes or motropes required to maintain a systolic blood pressure \>90 mm Hg in the absence of hypovolemia with signs of pulmonary congestion and signs of impaired organ perfusion defined by at least 1 of the following: altered mental status; cold, clammy skin; urine output \<30 mL/h; or arterial lactate \>2 mmol/L. 2\. Intubated and sedated Exclusion Criteria: 1. Self-ventilated 2. Indication for targeted temperature management by current guidelines "out of hospital cardiac arrest with return of spontaneous circulation (ROSC)"

Locations (1)

Tanta University

Tanta, El-Gharbia, Egypt

Outcomes

Primary Outcomes

Incidence of stroke

Incidence of stroke until day 30 was recorded.

Time frame: 30 day after the procedure

Secondary Outcomes

Duration of mechanical ventilation

Duration of mechanical ventilation was recorded.

Time frame: Up to 7 days

Length of intensive care unit stay

Length of intensive care unit (ICU) stay refers to the total duration a patient remains in the ICU, beginning from the moment of admission to the ICU until their discharge or transfer to a less intensive care setting, such as a regular hospital ward or home.

Time frame: Up to 2 weeks after the procedure

Duration of inotropic support

Duration of inotropic support was recorded.

Time frame: Intraoperatively

Incidence of mortality

Incidence of mortality was recorded.

Time frame: 30 days after the procedure

Data from ClinicalTrials.gov

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