The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus quickly closes itself. The persistent presence of ductus arteriosus leads to significant pressure changes in the systemic and pulmonary circulation, which have adverse effects on extremely/very premature infants. Therefore, persistent patent ductus arteriosus (PDA) is a systemic disease.
hemodynamic significant PDA(hsPDA) is a risk factor for intraventricular hemorrhage(IVH), bronchopulmonary dysplasia(BPD), necrotizing enterocolitis(NEC). A meta-analysis from Cochrane shows that compared to conservative treatment, drug therapy for PDA within 3 and 7 days after birth does not promote PDA closure and reduce the incidence of BPD. Therefore, there is currently a tendency not to provide medication intervention. Although ductus arteriosus quickly closes itself after birth in normal term infants, however, the dynamic changes detail of ductus arteriosus in preterm infants are unknown.
Study Type
OBSERVATIONAL
Enrollment
200
in the group, no intervention was given, and the preterm infants were diagnosed with respiratory distress syndrome(RDS)
in the group, no intervention was given, but the preterm infants were diagnosed without respiratory distress syndrome(RDS)
Women and Children's hospital of Chonqing Medical University
Chongqing, Chongqing Municipality, China
the incidence of patent ductus arteriosus(PDA)
when did the ductus arteriosus close
Time frame: three months after birth
dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow
dynamic changes of ductus arteriosus in diameter, velocity and direction of blood flow were measured
Time frame: after admission, 12 hour, 24 hour, 48 hour, 72 hour, 96 hour, 120 hour, 144 hour, 168 hour, 192 hour, 216 hour, 240 hour and 2 weeks or any time of ductus arteriosus closed
the incidence of bronchopulmonary dysplasia
whether or not bronchopulmonary dysplasia was assessed in 36 weeks' gestational age
Time frame: 36 weeks' gestational age
the incidence of intraventricular hemorrhage(IVH)
whether or not intraventricular hemorrhage(IVH) was assessed
Time frame: 36 weeks' gestational age
necrotizing enterocolotis(NEC)
whether or not NEC was assessed
Time frame: 36 weeks' gestational age
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